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Article

Caveolin-1 is required for contractile phenotype expression by airway smooth muscle cells.

Journal of cellular and molecular medicine - 1 Nov 2011

Gosens Reinoud, Stelmack Gerald L, Bos Sophie T, Dueck Gordon, Mutawe Mark M, Schaafsma Dedmer, Unruh Helmut, Gerthoffer William T, Zaagsma Johan, Meurs Herman, Halayko Andrew J

Abstract excerpt

Airway smooth muscle cells exhibit phenotype plasticity that underpins their ability to contribute both to acute bronchospasm and to the features of airway remodelling in chronic asthma. A feature of mature, contractile smooth muscle cells is the presence of abundant caveolae, plasma membrane invaginations that develop from the association of lipid rafts with caveolin-1, but the functional role of caveolae and...

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Identifiers

PMID: 21199324
DOI: 10.1111/j.1582-4934.2010.01246.x
PMCID: PMC3822954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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