Article
Laminin-binding integrin alpha7 is required for contractile phenotype expression by human airway myocytes.
American journal of respiratory cell and molecular biology - 1 Dec 2007
Tran Thai, Ens-Blackie Karen, Rector Edward S, Stelmack Gerald L, McNeill Karol D, Tarone Guido, Gerthoffer William T, Unruh Helmut, Halayko Andrew J
Abstract excerpt
Contractile airway smooth muscle (ASM) cells retain the ability for phenotype plasticity in response to multiple stimuli, which equips them with capacity to direct modeling and remodeling during development, and in disease states such as asthma. We have shown that endogenously expressed laminin is required for maturation of human ASM cells to a contractile phenotype, as occurs during ASM thickening in asthma. In...
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