Article
Up-regulation of KCa3.1 promotes human airway smooth muscle cell phenotypic modulation.
Pharmacological research - 1 Nov 2013
Yu Z-H, Wang Y-X, Song Y, Lu H-Z, Hou L-N, Cui Y-Y, Chen H-Z
Abstract excerpt
Airway smooth muscle (ASM) cell phenotype modulation, characterized by reversible switching between contractile and proliferative phenotypes, is considered to contribute to proliferative diseases such as allergic asthma and chronic obstructive pulmonary disease (COPD). KCa3.1 has been suggested to be involved in regulating ASM cell activation, proliferation, and migration. However, little is known regarding the...
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