Article
Glucocorticosteroids and β₂-adrenoceptor agonists synergize to inhibit airway smooth muscle remodeling.
The Journal of pharmacology and experimental therapeutics - 1 Sept 2012
Dekkers Bart G J, Pehlic Adnan, Mariani Raissa, Bos I Sophie T, Meurs Herman, Zaagsma Johan
Abstract excerpt
Airway remodeling, including increased airway smooth muscle (ASM) mass and contractility, contributes to increased airway narrowing in asthma. Increased ASM mass may be caused by exposure to mitogens, including platelet-derived growth factor (PDGF) and collagen type I, which induce a proliferative, hypocontractile ASM phenotype. In contrast, prolonged exposure to insulin induces a hypercontractile phenotype....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.