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Article

Liaisons between survivin and Plk1 during cell division and cell death.

The Journal of biological chemistry - 16 Jul 2010

Colnaghi Rita, Wheatley Sally P

Abstract excerpt

Survivin and Plk1 kinase are important mediators of cell survival that are required for chromosome alignment, cytokinesis, and protection from apoptosis. Interference with either survivin or Plk1 activity manifests many similar outcomes: prometaphase delay/arrest, multinucleation, and increased apoptosis. Moreover, the expression of both survivin and Plk1 is deregulated in cancer. Given these similarities, we...

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Identifiers

PMID: 20427271
DOI: 10.1074/jbc.M109.065003
PMCID: PMC2903399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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