Article
No evidence for mutations or altered expression of the Suppressor of Fused gene (SUFU) in primitive neuroectodermal tumours.
Neuropathology and applied neurobiology - 1 Oct 2004
Koch A, Waha A, Hartmann W, Milde U, Goodyer C G, Sörensen N, Berthold F, Digon-Söntgerath B, Krätzschmar J, Wiestler O D, Pietsch T
Abstract excerpt
The sonic hedgehog (Shh) and the Wnt signalling pathways are involved in the development of medulloblastomas (MBs), the most frequent malignant brain tumours in children. Components of these two developmental and cancer-associated pathways, including (Patched) PTCH, SMOH, adenomatous polyposis coli (APC), beta-catenin and AXIN1 show somatic mutations in sporadic MBs. In this study we analysed SUFU (human...
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