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Article

Patched Target Igf2 Is Indispensable for the Formation of Medulloblastoma and Rhabdomyosarcoma

1 Sept 2000

Abstract excerpt

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children (Dagher, R., and Helman, L. (1999) Oncologist 4, 34-44), whereas medulloblastoma, a highly malignant tumor of the cerebellum, accounts for 20% of childhood brain tumors (Goodrich, L. V., and Scott, M. P. (1998) Neuron 21, 1243-1257). Both tumors are associated with a deficiency in the tumor suppressor Patched (PTCH) in Gorlin syndrome...

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PMID: 10884376
DOI: 10.1074/jbc.c000352200

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