Article
Cnot7-null mice exhibit high bone mass phenotype and modulation of BMP actions.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2007
Washio-Oikawa Kaoru, Nakamura Takahisa, Usui Michihiko, Yoneda Mitsuhiro, Ezura Youichi, Ishikawa Isao, Nakashima Kazuhisa, Noda Tetsuo, Yamamoto Tadashi, Noda Masaki
Abstract excerpt
UNLABELLED: Cnot7 is a recently identified regulator of spermatogenesis in adult mice. Because Cnot7 binds to Tob, a BMP inhibitor shown to be involved in bone metabolism, we examined whether Cnot7 is involved in bone mass regulation by using adult Cnot7 deficient mice. Cnot7-/- mice exhibited a high bone mass phenotype. This was associated with an increase in bone formation rate but not with any alteration in...
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