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Article

Fibulin-7, a heparin binding matricellular protein, promotes renal tubular calcification in mice.

Matrix biology : journal of the International Society for Matrix Biology - 1 Dec 2018

Tsunezumi Jun, Sugiura Hidekazu, Oinam Lalhaba, Ali Aktar, Thang Bui Quoc, Sada Aiko, Yamashiro Yoshito, Kuro-O Makoto, Yanagisawa Hiromi

Abstract excerpt

Ectopic calcification occurs during development of chronic kidney disease and has a negative impact on long-term prognosis. The precise molecular mechanism and prevention strategies, however, are not established. Fibulin-7 (Fbln7) is a matricellular protein structurally similar to elastogenic short fibulins, shown to bind dental mesenchymal cells and heparin. Here, we report that Fbln7 is highly expressed in...

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PMID: 29730503
DOI: 10.1016/j.matbio.2018.04.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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