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Article

Obif, a Transmembrane Protein, Is Required for Bone Mineralization and Spermatogenesis in Mice

24 Jul 2015

Abstract excerpt

BACKGROUND: Various kinds of transmembrane and secreted proteins play pivotal roles in development through cell-cell communication. We previously reported that Obif (Osteoblast induction factor, Tmem119), encoding a single transmembrane protein, is expressed in differentiating osteoblasts, and that Obif-/- mice exhibit significantly reduced bone volume in the femur. In the current study, we characterized the Obif...

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PMID: 26207632
DOI: 10.1371/journal.pone.0133704

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