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Article

The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor.

The Journal of biological chemistry - 19 Jan 2007

Meadows Nicholas A, Sharma Sudarshana M, Faulkner Geoffrey J, Ostrowski Michael C, Hume David A, Cassady Alan I

Abstract excerpt

Microphthalmia transcription factor (MITF) regulates osteoclast function by controling the expression of genes, including tartrate-resistant acid phosphatase (TRAP) and cathepsin K in response to receptor activator of nuclear factor-kappaB ligand (RANKL)-induced signaling. To identify novel MITF target genes, we have overexpressed MITF in the murine macrophage cell line RAW264.7 subclone 4 (RAW/C4) and examined...

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Source

Identifiers

PMID: 17105730
DOI: 10.1074/jbc.M608572200

Genes

MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor.PMID 17105730Read ↗

Defective co-activator recruitment in osteoclasts from microphthalmia-oak ridge mutant mice.Semantic proximity Read ↗

Failure to Target RANKL Signaling Through p38-MAPK Results in Defective Osteoclastogenesis in the Microphthalmia Cloudy-Eyed Mutant.Semantic proximity Read ↗

The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts.Semantic proximity Read ↗

Microphthalmia Transcription Factor and PU.1 Synergistically Induce the Leukocyte Receptor Osteoclast-associated Receptor Gene ExpressionSemantic proximity Read ↗

ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function.Semantic proximity Read ↗

METTL21C is a potential pleiotropic gene for osteoporosis and sarcopenia acting through the modulation of the NF-κB signaling pathway.Semantic proximity Read ↗

Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMBSemantic proximity Read ↗

Mitf Induction by RANKL Is Critical for OsteoclastogenesisSemantic proximity Read ↗

OSTM1 regulates beta-catenin/Lef1 interaction and is required for Wnt/beta-catenin signaling.Semantic proximity Read ↗

Genomic analysis of the Microphthalmia locus and identification of the MITF-J/Mitf-J isoform.Semantic proximity Read ↗

Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation.Semantic proximity Read ↗

Mitf-D, a newly identified isoform, expressed in the retinal pigment epithelium and monocyte-lineage cells affected by Mitf mutations.Semantic proximity Read ↗

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