Article
Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta.
Nature genetics - 1 May 2004
Nakamura Takahisa, Yao Ryoji, Ogawa Takehiko, Suzuki Toru, Ito Chizuru, Tsunekawa Naoki, Inoue Kimiko, Ajima Rieko, Miyasaka Takashi, Yoshida Yutaka, Ogura Atsuo, Toshimori Kiyotaka, Noce Toshiaki, Yamamoto Tadashi, Noda Tetsuo
Abstract excerpt
Spermatogenesis is a complex process that involves cooperation of germ cells and testicular somatic cells. Various genetic disorders lead to impaired spermatogenesis, defective sperm function and male infertility. Here we show that Cnot7(-/-) males are sterile owing to oligo-astheno-teratozoospermia, suggesting that Cnot7, a CCR4-associated transcriptional cofactor, is essential for spermatogenesis. Maturation of...
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