Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantitative MRI reveals aging-associated T2 changes in mouse models of Alzheimer's disease.

NMR in biomedicine - 1 May 2007

Falangola M F, Dyakin V V, Lee S P, Bogart A, Babb J S, Duff K, Nixon R, Helpern J A

Abstract excerpt

In this study, we used MRI to analyze quantitative parametric maps of transverse (T(2)) relaxation times in a longitudinal study of transgenic mice expressing mutant forms of amyloid precursor protein (APP), presenilin (PS1), or both (PS/APP), modeling aspects of Alzheimer's disease (AD). The main goal was to characterize the effects of progressive beta-amyloid accumulation and deposition on the biophysical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Alzheimer Disease
Share to Cerebral Cortex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Hippocampus

Share to Least-Squares Analysis

Share to Magnetic Resonance Imaging

Source

Identifiers

PMID: 17451178
DOI: 10.1002/nbm.1163

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantitative MRI reveals aging-associated T2 changes in mouse models of Alzheimer's disease.PMID 17451178Read ↗

MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

Magnetic Resonance Imaging of Alzheimer's Pathology in the Brains of Living Transgenic Mice: A New Tool in Alzheimer's Disease ResearchSemantic proximity Read ↗

Striatum and entorhinal cortex atrophy in AD mouse models: MRI comprehensive analysis.Semantic proximity Read ↗

Neurofibrillary tangles and plaques are not accompanied by white matter pathology in aged triple transgenic-Alzheimer disease mice.Semantic proximity Read ↗

Brain Amyloidosis and BDNF Deficiency Have Opposite Effects on Brain Volumes in AβPP/PS1 Mice Both in vivo and ex vivo.Semantic proximity Read ↗

Disentangling molecular alterations from water-content changes in the aging human brain using quantitative MRISemantic proximity Read ↗

Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopySemantic proximity Read ↗

Early-in-life neuroanatomical and behavioural trajectories in a triple transgenic model of Alzheimer's disease.Semantic proximity Read ↗

Anatomical and functional phenotyping of mice models of Alzheimer's disease by MR microscopy.Semantic proximity Read ↗

Magnetic Resonance Imaging to Detect Early Molecular and Cellular Changes in Alzheimer's DiseaseSemantic proximity Read ↗

Age- and Brain Region-Specific Changes of Glucose Metabolic Disorder, Learning, and Memory Dysfunction in Early Alzheimer's Disease Assessed in APP/PS1 Transgenic Mice Using 18F-FDG-PET.Semantic proximity Read ↗

Diffusion MRI in 2-Month-Old Mouse Brain Predicts Alzheimer's Pathology Genotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.