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Article

Brain Amyloidosis and BDNF Deficiency Have Opposite Effects on Brain Volumes in AβPP/PS1 Mice Both in vivo and ex vivo.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Kärkkäinen Elisa, Lahtinen Hanna-Maija, Närväinen Johanna, Gröhn Olli, Tanila Heikki

Abstract excerpt

Magnetic resonance imaging (MRI) volumetry is widely used in Alzheimer's disease (AD) research and diagnostics alongside clinical assessment. Yet few MRI volumetry studies have been conducted in AD model mice with mixed results. We performed in vivo and ex vivo MRI and extensive postmortem histological analysis in transgenic mice derived from crossing amyloid plaque producing AβPP/PS1 mice with brain-derived...

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Source

Identifiers

PMID: 26402627
DOI: 10.3233/JAD-150059

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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