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Striatum and entorhinal cortex atrophy in AD mouse models: MRI comprehensive analysis.

Neurobiology of aging - 1 Feb 2015

Micotti Edoardo, Paladini Alessandra, Balducci Claudia, Tolomeo Daniele, Frasca Angelisa, Marizzoni Moira, Filibian Marta, Caroli Anna, Valbusa Giovanni, Dix Sophie, O'Neill Mike, Ozmen Laurence, Czech Christian, Richardson Jill C, Frisoni Giovanni B, Forloni Gianluigi

Abstract excerpt

Alzheimer's disease is experimentally modeled in transgenic (Tg) mice overexpressing mutated forms of the human amyloid precursor protein either alone or combined with mutated presenilins and tau. In the present study, we developed a systematic approach to compare double (TASTPM) and triple (APP/PS2/Tau) Tg mice by serial magnetic resonance imaging and spectroscopy analysis from 4 to 26 months of age to define...

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Identifiers

PMID: 25433456
DOI: 10.1016/j.neurobiolaging.2014.10.027

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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