Article
Age- and Brain Region-Specific Changes of Glucose Metabolic Disorder, Learning, and Memory Dysfunction in Early Alzheimer's Disease Assessed in APP/PS1 Transgenic Mice Using 18F-FDG-PET.
International journal of molecular sciences - 18 Oct 2016
Li Xue-Yuan, Men Wei-Wei, Zhu Hua, Lei Jian-Feng, Zuo Fu-Xing, Wang Zhan-Jing, Zhu Zhao-Hui, Bao Xin-Jie, Wang Ren-Zhi
Abstract excerpt
Alzheimer's disease (AD) is a leading cause of dementia worldwide, associated with cognitive deficits and brain glucose metabolic alteration. However, the associations of glucose metabolic changes with cognitive dysfunction are less detailed. Here, we examined the brains of APP/presenilin 1 (PS1) transgenic (Tg) mice aged 2, 3.5, 5 and 8 months using 18F-labed fluorodeoxyglucose (18F-FDG) microPET to assess age-...
Topics
- Aging
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Brain
- Cognition
- Disease Models, Animal
- Female
- Fluorodeoxyglucose F18
- Glucose
- Glucose Metabolism Disorders
- Hippocampus
- Humans