Article
MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease.
Magnetic resonance in medicine - 1 Apr 2004
Helpern Joseph A, Lee Sang-Pil, Falangola Maria F, Dyakin Victor V, Bogart Adam, Ardekani Babak, Duff Karen, Branch Craig, Wisniewski Thomas, de Leon Mony J, Wolf Oliver, O'Shea Jacqueline, Nixon Ralph A
Abstract excerpt
The cerebral deposition of amyloid beta-peptide, a central event in Alzheimer's disease (AD) pathogenesis, begins several years before the onset of clinical symptoms. Noninvasive detection of AD pathology at this initial stage would facilitate intervention and enhance treatment success. In this s...
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