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Article

PTEN is destabilized by phosphorylation on Thr366.

The Biochemical journal - 1 Aug 2007

Maccario Helene, Perera Nevin M, Davidson Lindsay, Downes C Peter, Leslie Nick R

Abstract excerpt

Although PTEN (phosphatase and tensin homologue deleted on chromosome 10) is one of the most commonly mutated tumour suppressors in human cancers, loss of PTEN expression in the absence of mutation appears to occur in an even greater number of tumours. PTEN is phosphorylated in vitro on Thr366 and Ser370 by GSK3 (glycogen synthase kinase 3) and CK2 (casein kinase 2) respectively, and specific inhibitors of these...

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Source

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Identifiers

PMID: 17444818
DOI: 10.1042/BJ20061837
PMCID: PMC2267318

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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