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Article

PTEN function: how normal cells control it and tumour cells lose it

10 Aug 2004

Abstract excerpt

The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation, survival and growth by inactivating PI 3-kinase-dependent signalling. It also suppresses cellular motility through mechanisms that may be partially independent of phosphatase activity. PTEN is one of the most commonly lost tumour suppressors in...

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PMID: 15193142
DOI: 10.1042/bj20040825

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