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Article

PTEN: its deregulation and tumorigenesis.

Biological & pharmaceutical bulletin - 1 Sept 2007

Maehama Tomohiko

Abstract excerpt

The tumor suppressor phosphatase and tensin homolog (PTEN) functions as a phosphoinositide 3-phosphatase, that antagonizes phosphatidylinositol 3-kinase action, and negatively regulates cell proliferation and survival signals. Inactivation of PTEN by loss-of-function mutations gives rise to deregulated hyperproliferation of cells, leading to oncogenic transformation. Recent studies have identified a number of...

Topics

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Cell Proliferation
Coagulation, Bradykinin, Polyphosphates, and Angioedema
PTEN gene
Mutation
Neoplasms
Phosphoinositide-3 Kinase Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

PI3K/AKT/mTOR signaling in cancer

PTEN Phosphohydrolase

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Identifiers

PMID: 17827710
DOI: 10.1248/bpb.30.1624

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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