Article
Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization.
Oncogene - 29 Jun 2017
Yang Jr-M, Schiapparelli P, Nguyen H-N, Igarashi A, Zhang Q, Abbadi S, Amzel L M, Sesaki H, Quiñones-Hinojosa A, Iijima M
Abstract excerpt
PTEN is a PIP3 phosphatase that antagonizes oncogenic PI3-kinase signalling. Due to its critical role in suppressing the potent signalling pathway, it is one of the most mutated tumour suppressors, especially in brain tumours. It is generally thought that PTEN deficiencies predominantly result from either loss of expression or enzymatic activity. By analysing PTEN in malignant glioblastoma primary cells derived...
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