Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphatase PTEN in neuronal injury and brain disorders.

Trends in neurosciences - 1 Nov 2007

Chang Ning, El-Hayek Youssef H, Gomez Everlyne, Wan Qi

Abstract excerpt

The phosphatase and tensin homologue PTEN was originally identified as a tumor suppressor. In the CNS, mutation or inactivation of PTEN is best known for playing a tumorigenic role in the molecular pathogenesis of glioblastoma. However, recent studies show that PTEN is associated with several brain diseases other than cancer, suggesting a broader role of PTEN in CNS pathophysiology. Here, we review the evidence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mental Disorders
Share to Brain Diseases
Share to Central Nervous System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PTEN gene

Share to Models, Biological

Share to Mutation

Share to Neurons

Share to PTEN Phosphohydrolase

Source

Identifiers

PMID: 17959258
DOI: 10.1016/j.tins.2007.08.006

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphatase PTEN in neuronal injury and brain disorders.PMID 17959258Read ↗

Function of PTEN during the formation and maintenance of neuronal circuits in the brain.Semantic proximity Read ↗

Tumours and tremors: how PTEN regulation underlies both.Semantic proximity Read ↗

Recent advances in PTEN signalling axes in cancerSemantic proximity Read ↗

PTENSemantic proximity Read ↗

The functions and regulation of the PTEN tumour suppressor.Semantic proximity Read ↗

The regulation of PTEN: Novel insights into functions as cancer biomarkers and therapeutic targetsSemantic proximity Read ↗

PTEN: Multiple Functions in Human Malignant TumorsSemantic proximity Read ↗

Decoding PTEN: from biological functions to signaling pathways in tumors.Semantic proximity Read ↗

The PTEN tumor suppressor gene and its role in lymphoma pathogenesis.Semantic proximity Read ↗

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.Semantic proximity Read ↗

PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypesSemantic proximity Read ↗

Therapeutic targeting of cancers with loss of PTEN function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.