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Article

Contribution of single nucleotide polymorphisms of the IL1A gene to the cleavage of precursor IL-1alpha and its transcription activity.

Immunogenetics - 1 Jun 2007

Kawaguchi Yasushi, Tochimoto Akiko, Hara Masako, Kawamoto Manabu, Sugiura Tomoko, Saito Seiji, Kamatani Naoyuki

Abstract excerpt

We previously demonstrated the association of IL1A gene single nucleotide polymorphisms (SNPs) with susceptibility to systemic sclerosis (SSc) patients. In this study, we explored the effects of SNP on the transcriptional activity and processing of the precursor IL-1alpha (pre-IL-1alpha) in skin fibroblasts. Two kinds of promoter regions of the IL1A gene were prepared including C or T at -889, referred to C/IL1A...

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PMID: 17440718
DOI: 10.1007/s00251-007-0213-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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