Article
Analysis of TIMP-1 gene polymorphisms in Italian sclerodermic patients.
Journal of clinical laboratory analysis - 1 Jan 2006
Indelicato Manuela, Chiarenza Valentina, Libra Massimo, Malaponte Grazia, Bevelacqua Valentina, Marchini Maurizio, McCubrey James A, Stivala Franca, Scorza Raffaella, Mazzarino Maria Clorinda
Abstract excerpt
Systemic sclerosis (SSc) is an autoimmune disease characterized by skin and internal organs fibrosis due to an extracellular matrix (ECM) accumulation of type I collagen. The turnover of the ECM is dependent on the balance between matrix metalloproteinases (MMPs) and tissue inhibitors of matrix m...
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