Article
The polymorphism of transforming growth factor-beta1 gene in Japanese patients with systemic sclerosis.
The British journal of dermatology - 1 Sept 2002
Ohtsuka T, Yamakage A, Yamazaki S
Abstract excerpt
BACKGROUND: Transforming growth factor (TGF)-beta has been shown to be a potent stimulator of collagen production by fibroblasts, and could play a role in the pathogenesis of systemic sclerosis (SSc). OBJECTIVE: To study the possible involvement of TGF-beta1 gene polymorphism in Japanese patients with SSc. METHODS: Fifty-nine patients with SSc and 110 normal subjects were studied. Genomic DNA was extracted from...
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