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Article

The -2518 promotor polymorphism in the MCP-1 gene is associated with systemic sclerosis.

The Journal of investigative dermatology - 1 Jan 2005

Karrer Sigrid, Bosserhoff Anja Kathrin, Weiderer Petra, Distler Oliver, Landthaler Michael, Szeimies Rolf-Markus, Müller-Ladner Ulf, Schölmerich Jürgen, Hellerbrand Claus

Abstract excerpt

Factors influencing the initiation or progression of sclerosis in patients with systemic sclerosis (SSc) are poorly understood. Monocyte chemotactic protein-1 (MCP-1) is a potent chemokine, which is upregulated in fibroblasts during development of sclerosis. In this study, we investigated the frequency of the functional -2518G MCP-1 promoter polymorphism in 18 patients with SSc and 139 healthy controls. In the...

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Source

Identifiers

PMID: 15654958
DOI: 10.1111/j.0022-202X.2004.23512.x

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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