Article
LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago.
American journal of human genetics - 1 Oct 2006
Zabetian Cyrus P, Hutter Carolyn M, Yearout Dora, Lopez Alexis N, Factor Stewart A, Griffith Alida, Leis Berta C, Bird Thomas D, Nutt John G, Higgins Donald S, Roberts John W, Kay Denise M, Edwards Karen L, Samii Ali, Payami Haydeh
Abstract excerpt
The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is the most common genetic determinant of Parkinson disease (PD) identified to date. It accounts for 1%-7% of PD in patients of European origin and 20%-40% in Ashkenazi Jews and North African Arabs with PD. Previous studies concluded that patients from these populations all shared a common Middle Eastern founder who lived in the 13th century. We tested this...
Topics
- Africa, Northern
- Amino Acid Substitution
- Case-Control Studies
- Family
- Female
- Haplotypes
- Humans
- Jews
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2