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Article

Rad51-dependent aberrant chromosome structures at telomeres and ribosomal DNA activate the spindle assembly checkpoint.

Molecular and cellular biology - 1 Apr 2014

Nakano Akemi, Masuda Kenta, Hiromoto Taisuke, Takahashi Katsunori, Matsumoto Yoshitake, Habib Ahmed G K, Darwish Ahmed G G, Yukawa Masashi, Tsuchiya Eiko, Ueno Masaru

Abstract excerpt

The spindle assembly checkpoint (SAC) monitors defects in kinetochore-microtubule attachment or lack of tension at kinetochores and arrests cells at prometaphase. In fission yeast, the double mutant between pot1Δ and the helicase-dead point mutant of the RecQ helicase Rqh1 gene (rqh1-hd) accumulates Rad51-dependent recombination intermediates at telomeres and enters mitosis with those intermediates. Here, we...

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Identifiers

PMID: 24469396
DOI: 10.1128/MCB.01704-13
PMCID: PMC3993586

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Rad51-dependent aberrant chromosome structures at telomeres and ribosomal DNA activate the spindle assembly checkpoint.PMID 24469396Read ↗

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