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Article

Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation.

Molecular and cellular biology - 1 Feb 2011

Takahashi Katsunori, Imano Ryota, Kibe Tatsuya, Seimiya Hiroyuki, Muramatsu Yukiko, Kawabata Naoki, Tanaka Genki, Matsumoto Yoshitake, Hiromoto Taisuke, Koizumi Yuka, Nakazawa Norihiko, Yanagida Mitsuhiro, Yukawa Masashi, Tsuchiya Eiko, Ueno Masaru

Abstract excerpt

Pot1 is a single-stranded telomere-binding protein that is conserved from fission yeast to mammals. Deletion of Schizosaccharomyces pombe pot1(+) causes immediate telomere loss. S. pombe Rqh1 is a homolog of the human RecQ helicase WRN, which plays essential roles in the maintenance of genomic stability. Here, we demonstrate that a pot1Δ rqh1-hd (helicase-dead) double mutant maintains telomeres that are dependent...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21098121
DOI: 10.1128/MCB.00613-10
PMCID: PMC3028624

Genes

WRN
POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation.PMID 21098121Read ↗

Fission yeast RecQ helicase Rqh1 is required for the maintenance of circular chromosomes.Semantic proximity Read ↗

A double mutant between fission yeast telomerase and RecQ helicase is sensitive to thiabendazole, an anti-microtubule drug.Semantic proximity Read ↗

Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe.Semantic proximity Read ↗

Helicase activity is only partially required for Schizosaccharomyces pombe Rqh1p function.Semantic proximity Read ↗

Rad51-dependent aberrant chromosome structures at telomeres and ribosomal DNA activate the spindle assembly checkpoint.Semantic proximity Read ↗

Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss.Semantic proximity Read ↗

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Semantic proximity Read ↗

POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.Semantic proximity Read ↗

Topoisomerase III is essential for accurate nuclear division in Schizosaccharomyces pombe.Semantic proximity Read ↗

Loss of hPot1 function leads to telomere instability and a cut-like phenotype.Semantic proximity Read ↗

Novel pof1 mutation suppresses the sensitivity to DNA replication inhibitor in fission yeast RecQ helicase mutant.Semantic proximity Read ↗

The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.Semantic proximity Read ↗

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