Article
A double mutant between fission yeast telomerase and RecQ helicase is sensitive to thiabendazole, an anti-microtubule drug.
Bioscience, biotechnology, and biochemistry - 1 Jan 2012
Ukimori Shinobu, Kawabata Naoki, Shimada Hideki, Imano Ryota, Takahashi Katsunori, Yukawa Masashi, Tsuchiya Eiko, Ueno Masaru
Abstract excerpt
In the fission yeast Schizosaccharomyces pombe, deletion of trt1(+) causes gradual telomere shortening, while deletion of pot1(+) causes rapid telomere loss. The double mutant between pot1 and RecQ helicase rqh1 is synthetically lethal. We found that the trt1 rqh1 double mutant was not synthetically lethal. The chromosome end fragments in both the trt1Δ rqh1Δ and the trt1Δ rqh1-hd (helicase dead) double mutants...
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