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Article

Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins.

Circulation. Cardiovascular genetics - 1 Apr 2014

Alves Marco L, Dias Fernando A L, Gaffin Robert D, Simon Jillian N, Montminy Eric M, Biesiadecki Brandon J, Hinken Aaron C, Warren Chad M, Utter Megan S, Davis Robert T, Sakthivel Sadayappan, Robbins Jeffrey, Wieczorek David F, Solaro R John, Wolska Beata M

Abstract excerpt

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common genetic disorder caused mainly by mutations in sarcomeric proteins and is characterized by maladaptive myocardial hypertrophy, diastolic heart failure, increased myofilament Ca(2+) sensitivity, and high susceptibility to sudden death. We tested the following hypothesis: correction of the increased myofilament sensitivity can delay or prevent the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24585742
DOI: 10.1161/CIRCGENETICS.113.000324
PMCID: PMC4061696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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