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Article

MDR1 gene polymorphisms and disposition of the P-glycoprotein substrate fexofenadine.

British journal of clinical pharmacology - 1 May 2002

Drescher Siegfried, Schaeffeler Elke, Hitzl Monika, Hofmann Ute, Schwab Matthias, Brinkmann Ulrich, Eichelbaum Michel, Fromm Martin F

Abstract excerpt

AIMS: The C3435T polymorphism in the human MDR1 gene is associated with lower intestinal P-glycoprotein expression, reduced protein function in peripheral blood cells and higher plasma concentrations of the P-glycoprotein substrate digoxin. Using fexofenadine, a known P-glycoprotein substrate, the hypothesis was tested whether this polymorphism also affects the disposition of other drugs in humans. METHODS: Ten...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11994059
DOI: 10.1046/j.1365-2125.2002.01591.x
PMCID: PMC1874364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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