Article
Roles of U4 and U6 snRNAs in the assembly of splicing complexes.
The EMBO journal - 1 Jan 1992
Vankan P, McGuigan C, Mattaj I W
Abstract excerpt
A series of U4 and U6 snRNA mutants was analysed in Xenopus oocytes to determine whether they block splicing complex assembly or splicing itself. All the U4 and U6 mutants found to be inactive in splicing complementation resulted in defects in assembly of either U4/U6 snRNP or of splicing complex...
Topics
- Animals
- Base Sequence
- Genetic Complementation Test
- Microinjections
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Nucleic Acid Conformation
- Oocytes
- RNA Splicing
- RNA, Small Nuclear
- Ribonucleoproteins
- Saccharomyces cerevisiae
- Xenopus