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Article

Mechanisms of polymorphonuclear neutrophil-mediated induction of HIV-1 replication in macrophages during pulmonary tuberculosis.

The Journal of infectious diseases - 1 May 2007

Hoshino Yoshihiko, Hoshino Satomi, Gold Jeffrey A, Raju Bindu, Prabhakar Savita, Pine Richard, Rom William N, Nakata Koh, Weiden Michael

Abstract excerpt

BACKGROUND: Pulmonary tuberculosis (TB) can present with polymorphonuclear neutrophil (PMN)-predominant alveolitis. TB accelerates acquired immunodeficiency syndrome by increasing human immunodeficiency virus type 1 (HIV-1) replication and mutation in alveolar macrophages. A 16-kDa CCAAAT/enhancer-binding protein beta (C/EBP beta ) isoform is a strong transcriptional repressor of the HIV long terminal repeat...

Read the complete abstract on PubMed

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Share to Acquired Immunodeficiency Syndrome
Share to Bronchoalveolar Lavage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Viral

Share to Leukocytes, Mononuclear

Share to Macrophages, Alveolar

Share to Mycobacterium tuberculosis

Share to Tuberculosis, Pulmonary

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Source

Identifiers

PMID: 17396999
DOI: 10.1086/513438

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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