Article

The immunosuppressive Tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells

2023-12-12

Abstract excerpt

<h4>Author Summary</h4> Mycobacterium tuberculosis ( Mtb ), the causative agent of tuberculosis (TB), is the most common coinfection among people living with HIV-1. This coinfection alters the efficacy of the immune response against both HIV-1 and Mtb , and is associated with accelerated HIV-1 disease progression and reduced survival. Enhanced HIV-1 replication in macrophages induced by Mtb coinfection may con...

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Literature Corpus work: 4ac5d3c3-917a-55b2-aa9a-8c348753f791
DOI: 10.1101/2023.12.05.570223

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