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Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

30 Mar 2020

Abstract excerpt

(Mtb) worsens HIV-1 pathogenesis remain scarce. We showed that HIV-1 infection is exacerbated in macrophages exposed to TB-associated microenvironments due to tunneling nanotube (TNT) formation. To identify molecular factors associated with TNT function, we performed a transcriptomic analysis in these macrophages, and revealed the up-regulation of Siglec-1 receptor. Siglec-1 expression depends on Mtb-induced...

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PMID: 32223897
DOI: 10.7554/elife.52535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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