Article

Concurrent TB and HIV therapies effectively control clinical reactivation of TB during co-infection but fail to eliminate chronic immune activation

2024-08-26

Abstract excerpt

<title>Abstract</title> The majority of Human Immunodeficiency Virus (HIV) negative individuals exposed to <italic>Mycobacterium tuberculosis</italic> ( <italic>Mtb</italic> ) control the bacillary infection as latent TB infection (LTBI). Co-infection with HIV, however, drastically increases the risk to progression to tuberculosis (TB) disease. TB is therefore the leading cause of death in people living...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 35cb85c6-d6d6-56bd-8a53-b397e7aa1ded
DOI: 10.21203/rs.3.rs-4908400/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Concurrent TB and HIV therapies effectively control clinical reactivation of TB during co-infection but fail to eliminate chronic immune activationDOI 10.21203/rs.3.rs-4908400/v1Read

Pre-existing SIV infection increases expression of T cell markers associated with activation during early Mycobacterium tuberculosis co-infection and impairs TNF responses in granulomasSemantic proximity Read

Antibiotic treatment modestly reduces protection against Mycobacterium tuberculosis reinfection in macaquesSemantic proximity Read

Control of Mycobacterium tuberculosis Infection in Lungs is Associated with Recruitment of Antigen-Specific Th1 and Th17 cells Co-expressing CXCR3 and CCR6Semantic proximity Read

HIV IMPAIRS AND EXPLOITS PULMONARY TH17 AND TH22 CELL-MEDIATED IMMUNE RESPONSES TO MYCOBACTERIUM TUBERCULOSISSemantic proximity Read

The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons.Semantic proximity Read

Single-Cell Transcriptomics of Mtb/HIV Co-InfectionSemantic proximity Read

CD8 + T cells mediate vaccination-induced lymphatic containment of latent Mycobacterium tuberculosis infection following immunosuppression, while B cells are dispensableSemantic proximity Read

Monkeying around with MAIT Cells: Studying the Role of MAIT Cells in SIV and Mtb Co-Infection.Semantic proximity Read

HIV Populations Shift After Tuberculosis Associated Immune Reconstitution Inflammatory Syndrome: Implications For HIV RemissionSemantic proximity Read

Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responsesSemantic proximity Read

Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape TownSemantic proximity Read

Global, regional, and national burden of HIV-negative tuberculosis, 1990–2021: Findings from the Global Burden of Disease 2021 StudySemantic proximity Read