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Article

Detailed phenotyping reveals diverse and highly skewed neutrophil subsets in both the blood and airways during active tuberculosis infection.

Frontiers in immunology - 1 Jan 2024

Nhamoyebonde Shepherd, Chambers Mark, Ndlovu Lerato, Karim Farina, Mazibuko Matilda, Mhlane Zoey, Madziwa Lindiwe, Moosa Yunus, Moodley Sashen, Hoque Monjurul, Leslie Alasdair

Abstract excerpt

Introduction: Neutrophils play a complex and important role in the immunopathology of TB. Data suggest they are protective during early infection but become a main driver of immunopathology if infection progresses to active disease. Neutrophils are now recognized to exist in functionally diverse states, but little work has been done on how neutrophil states or subsets are skewed in TB disease. Methods: To address...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38947330
DOI: 10.3389/fimmu.2024.1422836
PMCID: PMC11212598

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