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Article

Regulation of GTP cyclohydrolase I expression by orphan receptor Nurr1 in cell culture and in vivo.

Journal of neurochemistry - 1 Apr 2007

Gil Minchan, McKinney Cushla, Lee Mi Kyeong, Eells Jeffrey B, Phyillaier Marcia A, Nikodem Vera M

Abstract excerpt

Nurr1 is an orphan nuclear transcription factor essential for the terminal differentiation of dopamine (DA) neurons in the ventral midbrain (VM). To identify the Nurr1-target genes, we carried out microarray and quantitative real-time PCR analyses of Nurr1 null and wild-type mice in VM at embryonic day (E) 12.5 and shortly after birth (P0). In addition to the absence of mRNAs of DA synthesizing enzymes, the...

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Identifiers

PMID: 17394463
DOI: 10.1111/j.1471-4159.2006.04356.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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