Article
CB1 Cannabinoid Receptor-Dependent Activation of mTORC1/Pax6 Signaling Drives Tbr2 Expression and Basal Progenitor Expansion in the Developing Mouse Cortex.
Cerebral cortex (New York, N.Y. : 1991) - 1 Sept 2015
Díaz-Alonso Javier, Aguado Tania, de Salas-Quiroga Adán, Ortega Zaira, Guzmán Manuel, Galve-Roperh Ismael
Abstract excerpt
The CB1 cannabinoid receptor regulates cortical progenitor proliferation during embryonic development, but the molecular mechanism of this action remains unknown. Here, we report that CB1-deficient mouse embryos show premature cell cycle exit, decreased Pax6- and Tbr2-positive cell number, and reduced mammalian target of rapamycin complex 1 (mTORC1) activation in the ventricular and subventricular cortical zones....
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