Article
Clinical significance of K-ras and BRAF mutations in Chinese colorectal cancer patients.
World journal of gastroenterology - 14 Feb 2011
Shen Hong, Yuan Ying, Hu Han-Guang, Zhong Xian, Ye Xiao-Xian, Li Mo-Dan, Fang Wei-Jia, Zheng Shu
Abstract excerpt
AIM: To identify and assess mutations in the K-ras and BRAF genes in a cohort of Chinese patients with colorectal cancer (CRC) for their association with various clinicopathological parameters and prognosis. METHODS: Genomic DNA was isolated from frozen tissues. Pyrosequencing analysis was conducted to detect mutations in the K-ras (codons 12, 13, and 61) and BRAF genes (codon 600). Statistical analysis was...
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