Article
BRAF and K-ras gene mutations in human pancreatic cancers.
Cancer letters - 25 Sept 2003
Ishimura Norihisa, Yamasawa Kunihiro, Karim Rumi Mohammad Azharul, Kadowaki Yasunori, Ishihara Shunji, Amano Yuji, Nio Yoshinori, Higami Tetsuya, Kinoshita Yoshikazu
Abstract excerpt
We investigated the frequency of BRAF mutations in human pancreatic cancer specimens to determine its role in the development of pancreatic cancer. Nine pancreatic cancer samples without a K-ras codon 12 mutation and 19 with a K-ras mutation were included in the study. Analyses of the BRAF sequence revealed mutations in exon 15 (V599E) in two cases, both of which also exhibited a K-ras codon 12 mutation. No BRAF...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.