Article
High frequency of activated K-ras codon 15 mutant in colorectal carcinomas from Taiwanese patients.
International journal of cancer - 10 Nov 2003
Wang Jaw-Yuan, Hsieh Jan-Sing, Chen Fang-Ming, Yeh Ching-Sheng, Alexandersen Ketil, Huang Tsung-Jen, Chen David c p, Lin Shiu-Ru
Abstract excerpt
Colorectal carcinogenesis is regarded as a multistep process resulting from accumulation of genetic alterations, including activation of protooncogenes and inactivation of tumor suppressor genes via signal transduction trigger the stage-wise progression to malignancy. The reported incidence of K-ras mutation detected in general tissue samples ranges from 21-60% in primary colorectal cancers (CRC). To assess the...
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