Article
[BRAF gene mutation in wild-type KRAS patients with colorectal cancers].
Revista medica de Chile - 1 Jan 2014
Roa Iván, Game Anakaren, Bizama Carolina, Schalper Kurt
Abstract excerpt
BACKGROUND: In colorectal cancer, BRAF and KRAS mutation are mutually exclusive, but both are independent prognostic factors for the disease. AIM: To determine the frequency of BRAF V600E mutation in colorectal cancer. MATERIAL AND METHODS: A KRAS mutation study was carried out in 100 tissue samples of primary and metastatic adenocarcinomas of colon and rectum from patients aged 61.1 ± 62 years (56 women)....
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