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Article

BRAF mutations in sporadic colorectal carcinoma from polish patients.

Polish journal of pathology : official journal of the Polish Society of Pathologists - 1 Jan 2010

Wójcik Piotr, Okoń Krzysztof, Osuch Czesław, Klimkowska Agnieszka, Tomaszewska Romana

Abstract excerpt

BRAF mutations are second to KRAS mutations in activation of the MAPK pathway in colorectal carcinoma cells. In addition to mutated KRAS, BRAF V600E mutation is associated with resistance to EGFR-targeted therapy in colorectal cancer; thus mutated BRAF might serve as a predictive factor. In this study, 163 routinely resected adenocarcinomas were screened for mutations in exons 11 and 15 of the BRAF gene. Only 6...

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Identifiers

PMID: 20496269

Genes

BRAF
KRAS
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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