Article
RNAi knockdown of Nopp140 induces Minute-like phenotypes in Drosophila.
Molecular biology of the cell - 1 Jun 2007
Cui Zhengfang, DiMario Patrick J
Abstract excerpt
Nopp140 associates with small nucleolar RNPs to chaperone pre-rRNA processing and ribosome assembly. Alternative splicing yields two isoforms in Drosophila: Nopp140-True is homologous to vertebrate Nopp140 particularly in its carboxy terminus, whereas Nopp140-RGG contains a glycine and arginine-rich (RGG) carboxy terminus typically found in vertebrate nucleolin. Loss of ribosome function or production at critical...
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