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Article

Fibrillarin is essential for early development and required for accumulation of an intron-encoded small nucleolar RNA in the mouse.

Molecular and cellular biology - 1 Dec 2003

Newton Kathryn, Petfalski Elisabeth, Tollervey David, Cáceres Javier F

Abstract excerpt

Fibrillarin, a protein component of C/D box small nucleolar ribonucleoproteins (snoRNPs), directs 2'-O-methylation of rRNA and is also involved in other aspects of rRNA processing. A gene trap screen in embryonic stem (ES) cells resulted in an insertion mutation in the fibrillarin gene. This inse...

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Share to Chromosomal Proteins, Non-Histone
Share to Embryonic and Fetal Development
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Introns

Share to Mutagenesis, Insertional

Share to Recombinant Fusion Proteins

Share to RNA Processing, Post-Transcriptional

Share to RNA, Small Nucleolar

Source

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Identifiers

PMID: 14612397
DOI: 10.1128/MCB.23.23.8519-8527.2003
PMCID: PMC262675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14612397-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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