Article
Synthetic lethality with fibrillarin identifies NOP77p, a nucleolar protein required for pre-rRNA processing and modification.
The EMBO journal - 1 Jul 1994
Bergès T, Petfalski E, Tollervey D, Hurt E C
Abstract excerpt
The nucleolar protein fibrillarin (encoded by the NOP1 gene in yeast), is required for many post-transcriptional steps in yeast ribosome synthesis. A screen for mutations showing synthetic lethality with a temperature sensitive nop1-5 allele led to the identification of the NOP77 gene. NOP77 is essential for viability and encodes a nucleolar protein with a predicted molecular weight of 77 kDa. Depletion of NOP77p...
Topics
- Amino Acid Sequence
- Base Sequence
- Chromosomal Proteins, Non-Histone
- Cloning, Molecular
- DNA, Fungal
- Fungal Proteins
- Genes, Fungal
- Genes, Lethal
- Methylation
- Molecular Sequence Data
- Mutation