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Article

Synthetic lethality with fibrillarin identifies NOP77p, a nucleolar protein required for pre-rRNA processing and modification.

The EMBO journal - 1 Jul 1994

Bergès T, Petfalski E, Tollervey D, Hurt E C

Abstract excerpt

The nucleolar protein fibrillarin (encoded by the NOP1 gene in yeast), is required for many post-transcriptional steps in yeast ribosome synthesis. A screen for mutations showing synthetic lethality with a temperature sensitive nop1-5 allele led to the identification of the NOP77 gene. NOP77 is essential for viability and encodes a nucleolar protein with a predicted molecular weight of 77 kDa. Depletion of NOP77p...

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Identifiers

PMID: 8039506
DOI: 10.1002/j.1460-2075.1994.tb06612.x
PMCID: PMC395205

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Research trail→

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Synthetic lethality with fibrillarin identifies NOP77p, a nucleolar protein required for pre-rRNA processing and modification.PMID 8039506Read ↗

Temperature-sensitive mutations demonstrate roles for yeast fibrillarin in pre-rRNA processing, pre-rRNA methylation, and ribosome assembly.Semantic proximity Read ↗

Nucleolar protein Nop12p participates in synthesis of 25S rRNA in Saccharomyces cerevisiae.Semantic proximity Read ↗

The yeast nucleolar protein Nop4p contains four RNA recognition motifs necessary for ribosome biogenesis.Semantic proximity Read ↗

The yeast NOP4 gene product is an essential nucleolar protein required for pre-rRNA processing and accumulation of 60S ribosomal subunits.Semantic proximity Read ↗

Saccharomyces cerevisiae nucleolar protein Nop7p is necessary for biogenesis of 60S ribosomal subunits.Semantic proximity Read ↗

Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Rrp8p is a yeast nucleolar protein functionally linked to Gar1p and involved in pre-rRNA cleavage at site A2.Semantic proximity Read ↗

NOP3 is an essential yeast protein which is required for pre-rRNA processing.Semantic proximity Read ↗

Temperature sensitive nop2 alleles defective in synthesis of 25S rRNA and large ribosomal subunits in Saccharomyces cerevisiae.Semantic proximity Read ↗

Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 18S rRNA maturation.Semantic proximity Read ↗

rRNA maturation in yeast cells depleted of large ribosomal subunit proteins.Semantic proximity Read ↗

Nop6, a component of 90S pre-ribosomal particles, is required for 40S ribosomal subunit biogenesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

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