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Article

Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis.

Proceedings of the National Academy of Sciences of the United States of America - 3 Apr 2007

Kanin Elenita I, Kipp Ryan T, Kung Charles, Slattery Matthew, Viale Agnes, Hahn Steven, Shokat Kevan M, Ansari Aseem Z

Abstract excerpt

The process of gene transcription requires the recruitment of a hypophosphorylated form of RNA polymerase II (Pol II) to a gene promoter. The TFIIH-associated kinase Cdk7/Kin28 hyperphosphorylates the promoter-bound polymerase; this event is thought to play a crucial role in transcription initiation and promoter clearance. Studies using temperature-sensitive mutants of Kin28 have provided the most compelling...

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Identifiers

PMID: 17392431
DOI: 10.1073/pnas.0611505104
PMCID: PMC1851574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis.PMID 17392431Read ↗

Engineered Covalent Inactivation of TFIIH-Kinase Reveals an Elongation Checkpoint and Results in Widespread mRNA Stabilization.Semantic proximity Read ↗

Cyclin-Dependent Kinase 7 Controls mRNA Synthesis by Affecting Stability of Preinitiation Complexes, Leading to Altered Gene Expression, Cell Cycle Progression, and Survival of Tumor CellsSemantic proximity Read ↗

The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7.Semantic proximity Read ↗

Phosphorylation of the RNA polymerase II C-terminal domain by TFIIH kinase is not essential for transcription of Saccharomyces cerevisiae genome.Semantic proximity Read ↗

Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins.Semantic proximity Read ↗

Human PC4 is a substrate-specific inhibitor of RNA polymerase II phosphorylation.Semantic proximity Read ↗

Ccl1, a cyclin associated with protein kinase Kin28, controls the phosphorylation of RNA polymerase II largest subunit and mRNA transcription.Semantic proximity Read ↗

Mutations in the RING domain of TFB3, a subunit of yeast transcription factor IIH, reveal a role in cell cycle progression.Semantic proximity Read ↗

FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.Semantic proximity Read ↗

Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity.Semantic proximity Read ↗

Dominant-negative mutants reveal a role for the Cdk7 kinase at the mid-blastula transition in Drosophila embryos.Semantic proximity Read ↗

Rad25p, a DNA helicase subunit of yeast transcription factor TFIIH, is required for promoter escape in vivo.Semantic proximity Read ↗

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