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Article

Dominant-negative mutants reveal a role for the Cdk7 kinase at the mid-blastula transition in Drosophila embryos.

The EMBO journal - 3 Apr 2000

Leclerc V, Raisin S, Léopold P

Abstract excerpt

The metazoan cyclin-dependent kinase Cdk7 was purified originally as part of a biochemical activity called CAK (Cdk-activating kinase) capable of phosphorylating and activating in vitro the Cdks that promote the different cell cycle transitions. Cdk7 is also found in the transcription factor complex TFIIH, suggesting that it participates in vivo in the control of RNA polymerase II. We have examined the...

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Identifiers

PMID: 10747025
DOI: 10.1093/emboj/19.7.1567
PMCID: PMC310226

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Source receipt: pubmed, retrieved 7 Sept 2026.

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